Cilia‐Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury
Abstract: Following injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged muscle or muscular dystrophies. Fibro/adipogenic progenitors (FAPs) are key players in these events; however, the effect of primary cilia on FAPs remains unclear. Here, it is reported that genetic ablation of trichoplein (TCHP), a ciliary regulator, induces ciliary elongation on FAPs after injury, which promotes muscle regeneration while inhibiting adipogenesis. The defective adipogenic differentiation of FAPs is attributed to dysfunction of cilia‐dependent lipid raft dynamics, which is critical for insulin/Akt signaling. It is also found that interleukin (IL) 13 is substantially produced by intramuscular FAPs, which are upregulated by ciliary elongation and contribute to regeneration. Mechanistically, upon injury, long cilia excessively activate the IL33/ST2/JNK axis to enhance IL13 production, facilitating myoblast proliferation and M2 macrophage polarization. The results indicate that FAPs organize the regenerative responses to skeletal muscle injury via cilia‐mediated insulin/Akt and ST2/JNK signaling pathways.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Cilia‐Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury ; day:14 ; month:11 ; year:2022 ; extent:15
Advanced science ; (14.11.2022) (gesamt 15)
- Urheber
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Yamakawa, Daishi
Tsuboi, Junya
Kasahara, Kousuke
Matsuda, Chise
Nishimura, Yuhei
Kodama, Tatsuya
Katayama, Naoyuki
Watanabe, Masatoshi
Inagaki, Masaki
- DOI
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10.1002/advs.202202632
- URN
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urn:nbn:de:101:1-2022111414180467826594
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:29 MESZ
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Beteiligte
- Yamakawa, Daishi
- Tsuboi, Junya
- Kasahara, Kousuke
- Matsuda, Chise
- Nishimura, Yuhei
- Kodama, Tatsuya
- Katayama, Naoyuki
- Watanabe, Masatoshi
- Inagaki, Masaki
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